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Query: NC_010117:1633447 Coxiella burnetii RSA 331, complete genome

Start: 1633447, End: 1656445, Length: 22999

Host Lineage: Coxiella burnetii; Coxiella; Coxiellaceae; Legionellales; Proteobacteria; Bacteria

General Information: This strain (RSA 331; Hentzerling) is associated with acute Q fever and was isolated from the blood of an infected patient in northern Italy in 1945. This organism is widely distributed in nature and can cause infections in reptiles, birds, and mammals. It causes Q fever, or 'query' fever, an atypical pneumonia first associated with abattoir workers in Australia. Transmission may be through insect vectors such as ticks that have bitten an infected wild or domesticated animal, or through an aerosol produced by domesticated animals such as sheep or cattle. The presence of a plasmid is believed to be associated with virulence and pathogenicity, however C. burnetii isolates containing plasmid QpDG are avirulent in guinea pigs and plasmidless isolates have been associated with endocarditis in humans. Coxiella burnetii has a developmental life cycle, and can grow vegetatively through binary fission, or asymmetrically and produce a spore-like cell. The spore-like cell may enable the organism to exist extracellularly for small amounts of time. This bacterium is an obligate intracellular pathogen. It is endocytosed by a host cell, a macrophage for example, and lives and replicates inside the phagolysozome, a unique property of this organism. The genome encodes proteins that have a higher than average pI, which may enable adaptation to the acidic environment of the phagolysozome. The chromosome also contains genes for a number of detoxification and stress response proteins such as dismutases that allow growth in the oxidative environment. The type IV system is similar to the one found in Legionella, which may be important for intracellular survival. This organism produces numerous ankyrin-repeat proteins that may be involved in interactions with the host cell. The genome has 83 pseudogenes, which may be a result of the typical genome-wide degradation observed with other intracellular organisms and also has a group I intron in the 23S ribosomal RNA gene.

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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_011528:1769349*1769349179244023092Coxiella burnetii CbuK_Q154, complete genome013890BLASTN svgBLASTP svg
NC_002971:1545924*1545924156802322100Coxiella burnetii RSA 493, complete genome011990BLASTN svgBLASTP svg
NC_009727:357206*35720637934622141Coxiella burnetii Dugway 7E9-12, complete genome06127BLASTN svgBLASTP svg
NC_011527:953442*95344297731923878Coxiella burnetii CbuG_Q212, complete genome2e-34155BLASTN svgBLASTP svg
NC_009727:1001203*1001203102529924097Coxiella burnetii Dugway 7E9-12, complete genome1e-33153BLASTN svgBLASTP svg
NC_002971:951102*95110297443323332Coxiella burnetii RSA 493, complete genome2e-31145BLASTN svgBLASTP svg
NC_009727:11773901177390120051623127Coxiella burnetii Dugway 7E9-12, complete genome4e-30141BLASTN svgBLASTP svg
NC_002971:1379567*1379567140286123295Coxiella burnetii RSA 493, complete genome1e-1799.6BLASTN svgBLASTP svg
NC_002971:211331*21133124286731537Coxiella burnetii RSA 493, complete genome7e-1383.8BLASTN svgBLASTP svg
NC_010117:285230*28523030710321874Coxiella burnetii RSA 331, complete genome7e-1383.8BLASTN svgBLASTP svg
NC_011527:1688447*1688447171102422578Coxiella burnetii CbuG_Q212, complete genome7e-1383.8BLASTN svgBLASTP svg
NC_009727:1822877*1822877184654323667Coxiella burnetii Dugway 7E9-12, complete genome3e-1281.8BLASTN svgBLASTP svg
NC_011528:386417*38641740829821882Coxiella burnetii CbuK_Q154, complete genome2e-1075.8BLASTN svgBLASTP svg
NC_011528:1282691*1282691130313820448Coxiella burnetii CbuK_Q154, complete genome7e-1073.8BLASTN svgBLASTP svg
NC_011527:1443076*1443076146250819433Coxiella burnetii CbuG_Q212, complete genome7e-1073.8BLASTN svgBLASTP svg
NC_009727:1542000*1542000156409922100Coxiella burnetii Dugway 7E9-12, complete genome7e-1073.8BLASTN svgBLASTP svg