Pre_GI Gene

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Host: NC_009727 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009727:1542000 Coxiella burnetii Dugway 7E9-12, complete genome

Host Lineage: Coxiella burnetii; Coxiella; Coxiellaceae; Legionellales; Proteobacteria; Bacteria

General Information: Coxiella burnetii Dugway 5J108-111 was isolated from rodents in Utah, USA. This organism is widely distributed in nature and can cause infections in reptiles, birds, and mammals. It causes Q fever, or 'query' fever, an atypical pneumonia first associated with abattoir workers in Australia. Transmission may be through insect vectors such as ticks that have bitten an infected wild or domesticated animal, or through an aerosol produced by domesticated animals such as sheep or cattle. The presence of a plasmid is believed to be associated with virulence and pathogenicity, however C. burnetii isolates containing plasmid QpDG are avirulent in guinea pigs and plasmidless isolates have been associated with endocarditis in humans. Coxiella burnetii has a developmental life cycle, and can grow vegetatively through binary fission, or asymmetrically and produce a spore-like cell. The spore-like cell may enable the organism to exist extracellularly for small amounts of time. This bacterium is an obligate intracellular pathogen. It is endocytosed by a host cell, a macrophage for example, and lives and replicates inside the phagolysozome, a unique property of this organism. The genome encodes proteins that have a higher than average pI, which may enable adaptation to the acidic environment of the phagolysozome. The chromosome also contains genes for a number of detoxification and stress response proteins such as dismutases that allow growth in the oxidative environment. The type IV system is similar to the one found in Legionella, which may be important for intracellular survival. This organism produces numerous ankyrin-repeat proteins that may be involved in interactions with the host cell. The genome has 83 pseudogenes, which may be a result of the typical genome-wide degradation observed with other intracellular organisms and also has a group I intron in the 23S ribosomal RNA gene.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
15421531542323171hypothetical protein
154259815439531356amidohydrolase family proteinQuickGO ontologyBLASTP
15439401544839900hydroxymethylglutaryl-CoA lyaseQuickGO ontologyBLASTP
15448691545477609DedA family proteinQuickGO ontologyBLASTP
154553715475552019excinuclease ABC B subunitQuickGO ontologyBLASTP
154763615488201185aspartate aminotransferaseQuickGO ontologyBLASTP
1548875154895076tRNA-AsnQuickGO ontologyBLASTP
15491151549501387hypothetical protein
15581051558287183hypothetical proteinBLASTP
15588241559069246hypothetical proteinBLASTP
155945315608591407ankyrin repeat proteinQuickGO ontologyBLASTP
15611851561547363glyoxalase family proteinQuickGO ontologyBLASTP
15616281561744117hypothetical proteinBLASTP
15618791562529651ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
156252915637011173hypothetical proteinBLASTP
15636981563820123hypothetical proteinBLASTP