Pre_GI Gene

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Host: NC_008261 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008261:1099982 Clostridium perfringens ATCC 13124, complete genome

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: The species type strain, originally isolated from a human gas gangrene patient. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
109998211011571176hypothetical proteinBLASTP
11012261101693468phage terminase small subunitQuickGO ontologyBLASTP
110168611030501365putative phage terminase large subunitQuickGO ontologyBLASTP
11030641103873810hypothetical protein
110393711054391503putative phage minor capsid proteinQuickGO ontologyBLASTP
110542311070601638putative phage minor capsid proteinQuickGO ontologyBLASTP
11070731107297225hypothetical proteinBLASTP
11073251107942618hypothetical protein
11080361108641606hypothetical proteinBLASTP
11086661109571906putative phage major capsid proteinQuickGO ontologyBLASTP
11095861109855270hypothetical proteinBLASTP
11098911110253363hypothetical proteinBLASTP
11102571110583327hypothetical proteinBLASTP
11105831110966384hypothetical proteinBLASTP
11109661111352387hypothetical proteinBLASTP
11113621111820459hypothetical proteinBLASTP
11118331112201369hypothetical proteinBLASTP
11122901112523234hypothetical proteinBLASTP
111256411157763213hypothetical proteinBLASTP
11157801116133354hypothetical proteinBLASTP
11161561116422267hypothetical protein
11164891116869381hypothetical proteinBLASTP
111690511220135109KID repeat family proteinQuickGO ontologyBLASTP