Pre_GI Gene

Some Help

Host: NC_008258 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008258:3550500 Shigella flexneri 5 str. 8401, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Shigella spp. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
355073435518581125putative transporterQuickGO ontologyBLASTP
355185835545932736Hypothetical ABC transporter ATP-binding protein yhiHQuickGO ontologyBLASTP
355459035556571068hypothetical proteinBLASTP
355602335576451623hypothetical proteinBLASTP
355790735596821776hypothetical proteinBLASTP
35599573560445489hypothetical proteinBLASTP
35614683562232765hypothetical proteinBLASTP
35625113563239729hypothetical proteinBLASTP
35633463563858513hypothetical proteinBLASTP
356399735651451149putative fimbriae usherQuickGO ontologyBLASTP
35652373565602366IS2 ORF1QuickGO ontologyBLASTP
35656263566465840IS2 ORF2QuickGO ontologyBLASTP
35667203567712993probable fimbrial protein remnantQuickGO ontologyBLASTP
35678433568646804periplasmic fimbrial chaperone proteinQuickGO ontologyBLASTP
356980635710801275hypothetical proteinBLASTP
35710963571395300IS600 ORF1QuickGO ontologyBLASTP
35714063571801396IS1 ORF2QuickGO ontologyBLASTP
35719843572226243putative IS1 encoded proteinQuickGO ontologyBLASTP
357263235737861155hypothetical proteinBLASTP
357406335755621500low-affinity phosphate transportQuickGO ontologyBLASTP
35756333575968336hypothetical proteinBLASTP
35763593576793435universal stress proteinQuickGO ontologyBLASTP