Pre_GI Gene

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Host: NC_008258 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008258:2190635 Shigella flexneri 5 str. 8401, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Shigella spp. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
21906352191456822hypothetical proteinBLASTP
21915212192321801phosphomethylpyrimidine kinaseQuickGO ontologyBLASTP
21923182193106789hydoxyethylthiazole kinaseQuickGO ontologyBLASTP
21933292193601273hypothetical proteinBLASTP
21937232194571849hypothetical proteinBLASTP
21947902195128339hypothetical proteinBLASTP
21954282196243816putative type-1 fimbrial proteinQuickGO ontologyBLASTP
219625921987392481putative outer membrane proteinQuickGO ontologyBLASTP
21987552199318564putative chaperoneQuickGO ontologyBLASTP
21993772199880504IS1 ORF2QuickGO ontologyBLASTP
21999552200188234putative IS1 encoded proteinQuickGO ontologyBLASTP
22002872200829543putative fimbrial-like proteinQuickGO ontologyBLASTP
220166522027741110putative ATPaseQuickGO ontologyBLASTP
220290622049392034methionine tRNA synthetaseQuickGO ontologyBLASTP
22055122205637126IS600 ORF1QuickGO ontologyBLASTP
22057782206491714IS600 ORF2QuickGO ontologyBLASTP
220829522101391845putative molybdate metabolism regulatorQuickGO ontologyBLASTP