Pre_GI Gene

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Host: NC_008258 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008258:2045000 Shigella flexneri 5 str. 8401, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Shigella spp. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
20450372045246210putative outer membrane proteinQuickGO ontologyBLASTP
20457182045993276putative IS1 encoded proteinQuickGO ontologyBLASTP
20460682046571504IS1 ORF2QuickGO ontologyBLASTP
20466172047468852hypothetical proteinBLASTP
204757620489341359putative 2-component sensor proteinQuickGO ontologyBLASTP
20489342049716783putative 2-component transcriptional regulatorQuickGO ontologyBLASTP
20497382050151414hypothetical proteinBLASTP
20512652051900636hypothetical proteinBLASTP
20521582052808651hypothetical proteinBLASTP
20538862054155270hypothetical bacteriophage proteinQuickGO ontologyBLASTP
20542242054880657unknown protein encoded within prophageQuickGO ontologyBLASTP
205519620568391644invasion plasmid antigenQuickGO ontologyBLASTP
20570192057396378hypothetical bacteriophage proteinQuickGO ontologyBLASTP
20575392058252714IS600 ORF2QuickGO ontologyBLASTP
20583932058695303IS600 ORF1QuickGO ontologyBLASTP
20587522059120369ISSfl4 ORF3QuickGO ontologyBLASTP
20592982059573276ISSfl4 ORF3QuickGO ontologyBLASTP
20595702059920351ISSfl4 ORF2QuickGO ontologyBLASTP
20599172060591675ISSfl4 ORF1QuickGO ontologyBLASTP
20606902060905216hypothetical proteinBLASTP
2061198206127275tRNA-GlyQuickGO ontology
2061276206135176tRNA-ThrQuickGO ontology
2061354206143077tRNA-LysQuickGO ontology
2061432206150776tRNA-MetQuickGO ontologyBLASTP
20623852062750366putative endonuclease encoded by cryptic prophageQuickGO ontologyBLASTP