Pre_GI Gene

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Host: NC_007613 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007613:864084 Shigella boydii Sb227, complete genome

Host Lineage: Shigella boydii; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is an isolate from an epidemic that took place in China in the 1950s. Causes dysentery. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. Shigella boydii is uncommon except in India, where it was first isolated. Progression to clinical dysentery occurs in most patients infected with this organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
864084864674591glutamine amidotransferase subunit of heterodimer with HisFQuickGO ontologyBLASTP
864674865411738N-5-phospho-L-ribosyl-formimino-5-amino-1- 5- phosphoribosyl-4-imidazolecarboxamide isomeraseQuickGO ontologyBLASTP
865393866169777imidazole glycerol phosphate synthase subunit in heterodimer with HisHQuickGO ontologyBLASTP
866163866774612phosphoribosyl-amp cyclohydrolaseQuickGO ontologyBLASTP
8668718679051035regulator of length of O-antigen component of lipopolysaccharide chainsQuickGO ontologyBLASTP
868813869700888IS629 ORF2QuickGO ontologyBLASTP
869700869975276IS629 ORF1QuickGO ontologyBLASTP
870137870574438putative nucleotide sugar epimeraseQuickGO ontologyBLASTP
8706408718061167UDP-glucose 6-dehydrogenaseQuickGO ontologyBLASTP
8720558734071353gluconate-6-phosphate dehydrogenase decarboxylatingQuickGO ontologyBLASTP
8735878746631077putative glycosyl transferaseQuickGO ontologyBLASTP
8746358759271293O-antigen polymeraseQuickGO ontology
8759318769411011putative glycosyl transferaseQuickGO ontologyBLASTP
8770268782551230O-antigen flippaseQuickGO ontologyBLASTP
8782368793481113putative glycosyl transferaseQuickGO ontologyBLASTP
879345880187843putative glycosyl transferaseQuickGO ontologyBLASTP
880174880743570dTDP-4-dehydrorhamnose 35-epimeraseQuickGO ontologyBLASTP
880748881626879glucose-1-phosphate thymidylyltransferaseQuickGO ontologyBLASTP
881684882583900dTDP-6-deoxy-L-mannose-dehydrogenaseQuickGO ontologyBLASTP
8825838836681086dTDP-glucose 46 dehydrataseQuickGO ontologyBLASTP
884041884934894probable UDP-gal transferaseQuickGO ontologyBLASTP
8851098865031395hypothetical proteinBLASTP
8865148877341221putative colanic acid biosynthesis glycosyl transferaseQuickGO ontologyBLASTP
8877318890111281putative galactokinaseQuickGO ontologyBLASTP
8893838908611479probable export proteinQuickGO ontologyBLASTP
8908638922571395putative colanic acid biosynthsis UDP-glucose lipid carrier transferaseQuickGO ontologyBLASTP
8923128936821371phosphomannomutaseQuickGO ontologyBLASTP
8938758953111437mannose-1-phosphate guanyltransferaseQuickGO ontologyBLASTP