Pre_GI Gene

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Host: NC_007613 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007613:1533024 Shigella boydii Sb227, complete genome

Host Lineage: Shigella boydii; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is an isolate from an epidemic that took place in China in the 1950s. Causes dysentery. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. Shigella boydii is uncommon except in India, where it was first isolated. Progression to clinical dysentery occurs in most patients infected with this organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
15339441534219276IS629 ORF1QuickGO ontologyBLASTP
15342191535106888IS629 ORF2QuickGO ontologyBLASTP
15369741537294321hypothetical proteinBLASTP
15373241538070747hypothetical proteinBLASTP
154040915426882280putative oxidoreductase major subunitQuickGO ontologyBLASTP
15429361543133198hypothetical proteinBLASTP
15432081543969762putative ARAC-type regulatory proteinQuickGO ontologyBLASTP
154437115460531683putative sulfataseQuickGO ontologyBLASTP
154609015472621173putative enzymeQuickGO ontologyBLASTP
154928215516542373hypothetical proteinBLASTP
155169915544942796putative peptidaseQuickGO ontologyBLASTP
155485615562561401glutamate decarboxylase isozymeQuickGO ontologyBLASTP
155641215579471536acid sensitivity protein putative transporterQuickGO ontologyBLASTP
155807815593971320hypothetical proteinBLASTP