Pre_GI Gene

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Host: NC_007530 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007530:4853740 Bacillus anthracis str. 'Ames Ancestor', complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This is the type strain (0581, A2084, genotype 62, Group A3.b) for Bacillus anthracis and contains the two virulence plasmids, pOX1 and pOX2, that encode anthrax toxin and capsule, respectively, making this a virulent strain. This strain is considered the "gold standard" for B. anthracis. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
485245848537681311hypothetical proteinBLASTP
48537404854237498prophage lambdaba03 prohead protease putativeQuickGO ontologyBLASTP
485429748553371041phage major capsid protein hk97 familyQuickGO ontologyBLASTP
48554244856404981hypothetical proteinBLASTP
48564724857338867hypothetical proteinBLASTP
48574614858366906prophage lambdaba03 site-specific recombinase phage integrase familyQuickGO ontologyBLASTP
485851048598051296enolaseQuickGO ontologyBLASTP
485983648613651530phosphoglyceromutaseQuickGO ontologyBLASTP
48613624862117756triosephosphate isomeraseQuickGO ontologyBLASTP
486215048633341185phosphoglycerate kinaseQuickGO ontologyBLASTP
486347448644781005glyceraldehyde-3-phosphate dehydrogenaseQuickGO ontologyBLASTP
486450548655331029gapa transcriptional regulator cggrQuickGO ontologyBLASTP
48656704865915246glutaredoxin family proteinQuickGO ontologyBLASTP
486592548672321308DNA-directed RNA polymerase subunit NQuickGO ontologyBLASTP
4867488486756679tRNA-ArgQuickGO ontologyBLASTP
48677724867978207hypothetical proteinBLASTP
48680724868557486lipoprotein putativeQuickGO ontologyBLASTP
48685884869064477stage v sporulation protein acQuickGO ontologyBLASTP
486906548700811017stage V sporulation protein SpoVADQuickGO ontologyBLASTP
48700784870428351stage v sporulation protein aeQuickGO ontologyBLASTP
48704404870646207hypothetical proteinBLASTP
48706674871536870hypothetical proteinBLASTP
48717784872359582ATP-dependent Clp protease proteolytic subunitQuickGO ontologyBLASTP
48726834872931249phosphocarrier protein hprQuickGO ontologyBLASTP
48729554873905951hypothetical proteinBLASTP
48739954874948954hypothetical proteinBLASTP