Pre_GI Gene

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Host: NC_007530 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007530:3749645 Bacillus anthracis str. 'Ames Ancestor', complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This is the type strain (0581, A2084, genotype 62, Group A3.b) for Bacillus anthracis and contains the two virulence plasmids, pOX1 and pOX2, that encode anthrax toxin and capsule, respectively, making this a virulent strain. This strain is considered the "gold standard" for B. anthracis. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
37496453750226582hypothetical proteinBLASTP
37502903750994705prophage lambdaba02 n-acetylmuramoyl-l-alanine amidase family 2QuickGO ontologyBLASTP
37509943751419426prophage lambdaba02 holin putativeQuickGO ontologyBLASTP
37514243752401978prophage lambdaba02 site-specific recombinase phage integrase familyQuickGO ontologyBLASTP
37525483752823276prophage lambdaba02 transcriptional regulator abrb familyQuickGO ontologyBLASTP
375284837549622115hypothetical proteinBLASTP
375495037569321983phage minor structural proteinQuickGO ontologyBLASTP
375692937584101482hypothetical proteinBLASTP
37584473759058612hypothetical proteinBLASTP
375912437605121389hypothetical proteinBLASTP
376058137634602880prophage lambdaba02 tape measure protein putativeQuickGO ontologyBLASTP
37634763763616141hypothetical proteinBLASTP
37636183764028411hypothetical proteinBLASTP
37640883764672585prophage lambdaba02 major tail protein putativeQuickGO ontologyBLASTP
37646863765045360hypothetical proteinBLASTP
37650423765479438hypothetical proteinBLASTP
37654673765823357hypothetical proteinBLASTP
37658013766076276hypothetical proteinBLASTP
37660853766285201hypothetical proteinBLASTP
376636237675491188prophage lambdaba02 major capsid protein putativeQuickGO ontologyBLASTP
37675463768301756prophage lambdaba02 clp protease family proteinQuickGO ontologyBLASTP
376827937694481170hypothetical proteinBLASTP