Pre_GI Gene

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Host: NC_005956 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005956:1221352 Bartonella henselae str. Houston-1, complete genome

Host Lineage: Bartonella henselae; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: Bartonella henselae str. Houston-1 (ATCC 49882) was isolated from human blood in Houston Texas. Causative agent of cat scratch fever. This group of alpha proteobacteria are unique among pathogens in that they cause angiogenic lesions. This organism was identified as the causative agent of cat scratch fever, a disease found commonly in children or in immunocompromised adults. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
12213521222221870ribosomal protein L11 methyltransferaseQuickGO ontologyBLASTP
122223912240651827Aminopeptidase p proteinQuickGO ontologyBLASTP
122599812281482151DNA ligaseQuickGO ontologyBLASTP
122828012299411662DNA repair protein recnQuickGO ontologyBLASTP
12299481230841894Competence lipoprotein comL precursorQuickGO ontologyBLASTP
12310131231888876UDP-3-o-3-hydroxymyristoyl N-acetylglucosamine deacetylaseQuickGO ontologyBLASTP
123209412338391746cell division protein FtsZQuickGO ontologyBLASTP
123390912352071299Cell division protein ftsAQuickGO ontologyBLASTP
12352071236139933Cell division protein ftsQQuickGO ontologyBLASTP
12361061237026921D-alanylalanine synthetaseQuickGO ontologyBLASTP
123725312383081056UDP-N-acetylenolpyruvoylglucosamine reductaseQuickGO ontologyBLASTP
123820812396351428UDP-N-acetylmuramate--L-alanine ligaseQuickGO ontologyBLASTP
123961912407551137N-acetylglucosaminyl transferaseQuickGO ontologyBLASTP
124074812419021155Cell division protein ftsWQuickGO ontologyBLASTP
124203412434341401UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetaseQuickGO ontologyBLASTP