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Query: NC_005956:1221352 Bartonella henselae str. Houston-1, complete genome

Start: 1221352, End: 1243434, Length: 22083

Host Lineage: Bartonella henselae; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: Bartonella henselae str. Houston-1 (ATCC 49882) was isolated from human blood in Houston Texas. Causative agent of cat scratch fever. This group of alpha proteobacteria are unique among pathogens in that they cause angiogenic lesions. This organism was identified as the causative agent of cat scratch fever, a disease found commonly in children or in immunocompromised adults. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells.

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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_005955:1029435*1029435105559926165Bartonella quintana str. Toulouse, complete genome010220BLASTN svgBLASTP svg
NC_020301:11329271132927115809925173Bartonella vinsonii subsp. berkhoffii str. Winnie, complete genome06738BLASTN svgBLASTP svg
NC_012846:15510001551000157244221443Bartonella grahamii as4aup, complete genome05612BLASTN svgBLASTP svg
NC_014932:10844221084422110853724116Bartonella clarridgeiae 73, complete genome01925BLASTN svgBLASTP svg
NC_020300:10415231041523106613924617Bartonella australis Aust/NH1, complete genome01409BLASTN svgBLASTP svg
NC_019907:773944*77394479930425361Liberibacter crescens BT-1 chromosome, complete genome7e-1073.8BLASTN svgBLASTP svg
NC_006142:811469*81146983714125673Rickettsia typhi str. Wilmington, complete genome2e-0765.9BLASTN svgBLASTP svg