Pre_GI Gene

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Host: NC_005810 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005810:2905362 Yersinia pestis biovar Microtus str. 91001, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
290536229067111350putative two-component system sensor kinaseQuickGO ontologyBLASTP
29067372907420684putative two-component system response regulatorQuickGO ontologyBLASTP
290760829088131206HlyD family secretion proteinQuickGO ontologyBLASTP
290881729108532037putative ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
291110829127541647putative pyridine nucleotide-disulphide oxidoreductaseQuickGO ontologyBLASTP
291281429142741461putative permeaseQuickGO ontologyBLASTP
29142712914468198hypothetical proteinBLASTP
291586429170901227putative aminotransferaseQuickGO ontologyBLASTP
291764229191711530hypothetical proteinBLASTP
291940429209481545putative two-component sensor histidine kinaseQuickGO ontologyBLASTP
29209452921652708putative response regulatorQuickGO ontologyBLASTP
292203329232651233hypothetical proteinBLASTP
29235102924388879cysteine synthase BQuickGO ontologyBLASTP
292455929256501092sulfatethiosulfate transporter subunitQuickGO ontologyBLASTP
29256402926515876sulfatethiosulfate transporter permease subunitQuickGO ontologyBLASTP
29265152927348834sulfatethiosulfate transporter subunitQuickGO ontologyBLASTP
292734829283851038thiosulfate transporter subunitQuickGO ontologyBLASTP