Pre_GI: BLASTP Hits

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Query: NC_005810:2905362:2914271 Yersinia pestis biovar Microtus str. 91001, complete genome

Start: 2914271, End: 2914468, Length: 198

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017265:1346685:135786613578661358063198Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,hypothetical protein1e-22105
NC_017168:2394079:240612624061262406323198Yersinia pestis A1122 chromosome, complete genomehypothetical protein1e-22105
NC_010465:1550617:156639515663951566592198Yersinia pseudotuberculosis YPIII, complete genomehypothetical protein1e-22105
NC_010634:3129174:313808331380833138280198Yersinia pseudotuberculosis PB1/+, complete genomehypothetical protein1e-22105
NC_003143:3346834:335574333557433355940198Yersinia pestis CO92, complete genomehypothetical protein1e-22105
NC_006155:3212796:322033032203303220527198Yersinia pseudotuberculosis IP 32953, complete genomehypothetical protein1e-22105
NC_007952:1934249:193981119398111940026216Burkholderia xenovorans LB400 chromosome 2, complete sequencehypothetical protein2e-0857.8
NC_015660:1869962:187473518747351874935201Geobacillus thermoglucosidasius C56-YS93 chromosome, completehypothetical protein8e-0855.8