Pre_GI Gene

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Host: NC_004337 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004337:1065609 Shigella flexneri 2a str. 301, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain was isolated in 1984 from a patient in Beijing, China. It is similar to pathogenic Escherichia coli except for the more numerous insertion sequences and contains a virulence plasmid (pCP301). Causes enteric disease. Shigella This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
106560910667361128hypothetical proteinBLASTP
106674210680071266hypothetical proteinBLASTP
10684791069402924putative ATP-binding proteinQuickGO ontologyBLASTP
10695121070378867IS3 ORF2QuickGO ontologyBLASTP
10703751070683309IS3 ORF1QuickGO ontologyBLASTP
10712661072252987hypothetical proteinBLASTP
1072445107253288tRNA-SerQuickGO ontologyBLASTP
10737601074497738hypothetical proteinBLASTP
10745211075075555putative oxidoreductase componentQuickGO ontologyBLASTP
10751471075668522hypothetical proteinBLASTP
107677210779801209iso-IS10R ORFQuickGO ontologyBLASTP
10783131078702390Curli production assemblytransport component CsgE precursorQuickGO ontologyBLASTP
10787071079357651probable csgAB operon transcriptional regulatory proteinQuickGO ontologyBLASTP
10801111080566456minor curlin subunit precursorQuickGO ontologyBLASTP
10807801081082303IS600 ORF1QuickGO ontologyBLASTP
10811181081861744IS600 ORF2QuickGO ontologyBLASTP
10822661082598333putative curli production proteinQuickGO ontologyBLASTP
10827191083030312hypothetical proteinBLASTP
10831251083658534hypothetical proteinBLASTP
108360010850811482putative synthaseQuickGO ontologyBLASTP
108508910862461158glucans biosynthesis proteinQuickGO ontologyBLASTP
108664010881751536periplasmic glucans biosynthesis proteinQuickGO ontologyBLASTP
108816810907112544glucosyltransferase MdoHQuickGO ontologyBLASTP