Pre_GI Gene

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Host: NC_003888 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003888:1395319 Streptomyces coelicolor A3(2), complete genome

Host Lineage: Streptomyces coelicolor; Streptomyces; Streptomycetaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Well-studied antiobiotic-producing bacterium. These bacteria are widely distributed in nature, especially in the soil. The characteristic earthy smell of freshly plowed soil is actually attributed to the aromatic terpenoid geosmin produced by species of Streptomyces. There are currently 364 known species of this genus, many of which are the most important industrial producers of antibiotics and other secondary metabolites of antibacterial, antifungal, antiviral, and antitumor nature, as well as immunosuppressants, antihypercholesterolemics, etc. Streptomycetes are crucial in the soil environment because their diverse metabolism allows them to degrade the insoluble remains of other organisms, including recalcitrant compounds such as lignocelluloses and chitin. Streptomycetes produce both substrate and aerial mycelium. The latter shows characteristic modes of branching, and in the course of the streptomycete complex life cycle, these hyphae are partly transformed into chains of spores, which are often called conidia or arthrospores. An important feature in Streptomyces is the presence of type-I peptidoglycan in the cell walls that contains characteristic interpeptide glycine bridges. Another remarkable trait of streptomycetes is that they contain very large (~8 million base pairs which is about twice the size of most bacterial genomes) linear chromosomes with distinct telomeres. These rearrangements consist of the deletion of several hundred kilobases, often associated with the amplification of an adjacent sequence, and lead to metabolic diversity within the Streptomyces group. Sequencing of several strains of Streptomyces is aimed partly on understanding the mechanisms involved in these diversification processes. This bacterium is a soil-dwelling filamentous organism responsible for producing more than half of the known natural antibiotics. It is a well-studied species of Streptomyces and genetically is the best known representative.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
13953191396164846hypothetical proteinBLASTP
139623813974161179elongation factor TU-3QuickGO ontologyBLASTP
13975081398413906hypothetical proteinBLASTP
13984631399239777integral membrane proteinQuickGO ontologyBLASTP
1399280140044911703-ketoacyl-CoA thiolaseacetyl-CoA acetyltransferaseQuickGO ontologyBLASTP
14005841401057474hypothetical proteinBLASTP
14012071402082876undecaprenyl pyrophosphate phosphataseQuickGO ontologyBLASTP
140257414037371164integral membrane proteinQuickGO ontologyBLASTP
14037091404566858hypothetical protein
14048011405034234hypothetical protein
140503114061131083fatty acid CoA ligaseQuickGO ontologyBLASTP
140613814084802343multi-domain regulatory proteinQuickGO ontologyBLASTP
14088501409722873hypothetical proteinBLASTP
14100271410995969integral membrane proteinQuickGO ontology
14116471411826180hypothetical proteinBLASTP
14118851412625741oxidoreductaseQuickGO ontologyBLASTP
141277414143481575lipoprotein N-acyltransferase integral membraneQuickGO ontologyBLASTP
14142721415177906oxidoreductaseQuickGO ontologyBLASTP
141519114163811191monooxygenase secreted proteinQuickGO ontologyBLASTP
14164841417104621hypothetical proteinBLASTP
14171471417659513hypothetical proteinBLASTP
14177631418269507lipoproteinQuickGO ontology