Pre_GI Gene

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Host: NC_003143 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003143:2804500 Yersinia pestis CO92, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is a recent Orientalis subtype isolated in the USA from a patient who died of pneumonic plague after acquiring the disease from an infected cat. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
28045282804710183hypothetical proteinBLASTP
280477928058761098tartrate dehydrogenaseQuickGO ontologyBLASTP
28059672806908942putativeLlysR-family transcriptional regulatory proteinQuickGO ontologyBLASTP
280715528081591005putative LacI-family transcriptional regulatory proteinQuickGO ontologyBLASTP
28082922809284993putative sugar transport system permease proteinQuickGO ontologyBLASTP
280928128107711491putative sugar transport system ATP-binding proteinQuickGO ontologyBLASTP
28108112811728918sugar binding protein precursorQuickGO ontologyBLASTP
281190328131291227putative zinc-binding dehydrogenaseQuickGO ontologyBLASTP
28137122814380669hypothetical proteinBLASTP
28145762815118543hypothetical proteinBLASTP
28153562816294939hypothetical proteinBLASTP
28166102817134525outer membrane protein XQuickGO ontologyBLASTP
28175392818426888hypothetical proteinBLASTP
28184422818939498hypothetical proteinBLASTP
28189622819738777trans-aconitate 2-methyltransferaseQuickGO ontologyBLASTP
28199952820498504DNA protection during starvation conditionsQuickGO ontologyBLASTP
282081828219451128hypothetical proteinBLASTP