Pre_GI Gene

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Host: NC_002950 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_002950:155873 Porphyromonas gingivalis W83, complete genome

Host Lineage: Porphyromonas gingivalis; Porphyromonas; Porphyromonadaceae; Bacteroidales; Bacteroidetes; Bacteria

General Information: This strain (also known as HG66) is virulent in a mouse model and has been extensively studied. It was originally isolated by H. Werner in the 1950s in Bonn, Germany, from an unknown human infection. Associated with severe and chronic periodontal disease. This organism is associated with severe and chronic periodontal (tissues surrounding and supporting the tooth) diseases. Progression of the disease is caused by colonization by this organism in an anaerobic environment in host tissues and severe progression results in loss of the tissues supporting the tooth and eventually loss of the tooth itself. The black pigmentation characteristic of this bacterium comes from iron acquisition that does not use the typical siderophore system of other bacteria but accumulates hemin.Peptides appear to be the predominant carbon and energy source of this organism, perhaps in keeping with its ability to destroy host tissue. Oxygen tolerance systems play a part in establishment of the organism in the oral cavity, including a superoxide dismutase. Pathogenic factors include extracellular adhesins that mediate interactions with other bacteria as well as the extracellular matrix, and a host of degradative enzymes that are responsible for tissue degradation and spread of the organism including the gingipains, which are trypsin-like cysteine proteases.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
1558731572251353magnesium transporterQuickGO ontologyBLASTP
157257158033777dimethyladenosine transferaseQuickGO ontologyBLASTP
1581641592131050hypothetical proteinBLASTP
1592441606981455aminoacyl-histidine dipeptidaseQuickGO ontologyBLASTP
160813161694882malonyl CoA-acyl carrier protein transacylaseQuickGO ontologyBLASTP
1618761632311356membrane-bound lytic murein transglycosylase D putativeQuickGO ontologyBLASTP
163241163948708hypothetical proteinBLASTP
163968164837870spoOJ proteinQuickGO ontologyBLASTP
164845165621777SpoOJ regulator proteinQuickGO ontologyBLASTP
165837166715879hydrolase carbon-nitrogen familyQuickGO ontologyBLASTP
1667331677581026hypothetical proteinBLASTP
167971168549579hypothetical protein
168498169205708hypothetical proteinBLASTP
169218169757540hypothetical proteinBLASTP
1697441709971254sigma-54-dependent transcriptional regulatorQuickGO ontologyBLASTP
1710251722931269hypothetical proteinBLASTP
1723301736341305conserved hypothetical protein TIGR01125QuickGO ontologyBLASTP
173631174584954signal recognition particle-docking protein FtsYQuickGO ontologyBLASTP
1746111757471137carboxynorspermidine decarboxylaseQuickGO ontologyBLASTP
1757571775201764aspartyl-tRNA synthetaseQuickGO ontologyBLASTP
177951178943993riboflavin biosynthesis protein RibDQuickGO ontologyBLASTP
178968179849882modification methylase HemK familyQuickGO ontologyBLASTP
179846180331486regulatory protein RecXQuickGO ontologyBLASTP
180315181055741competence protein F-related proteinQuickGO ontologyBLASTP
1811851832542070endopeptidase PepOQuickGO ontologyBLASTP