NC_010488:48868 Escherichia coli SMS-3-5 plasmid pSMS35_130, complete sequence
Host Lineage: Escherichia coli; Escherichia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria
General Information: Escherichia coli SMS-3-5 was isolated from a toxic-metal contaminated site, Shipyard Creek, Charleston, South Carolina, USA. This strain is highly resistant to a number of antibiotics. This organism was named for its discoverer, Theodore Escherich, and is one of the premier model organisms used in the study of bacterial genetics, physiology, and biochemistry. This enteric organism is typically present in the lower intestine of humans, where it is the dominant facultative anaerobe present, but it is only one minor constituent of the complete intestinal microflora. E. coli, is capable of causing various diseases in its host, especially when they acquire virulence traits. E. coli can cause urinary tract infections, neonatal meningitis, and many different intestinal diseases, usually by attaching to the host cell and introducing toxins that disrupt normal cellular processes.