NC_002940:1065246 Haemophilus ducreyi 35000HP, complete genome
Host Lineage: Haemophilus ducreyi; Haemophilus; Pasteurellaceae; Pasteurellales; Proteobacteria; Bacteria
General Information: This strain is a human passage derivative of Haemophilus ducreyi strain 35000 that is serum-resistant. Causative agent of chancroid. A group of organisms that are either obligate parasites or commensal organisms found in animal mucous membranes. Almost all species require the presence of important growth factors found in the blood of their hosts, including either X factor (protoporphyrin IX or heme) or V factor (nicotinamide adenine dinucleotide (NAD or NADP)). This organism is an obligate human pathogen that causes the sexually transmitted disease chancroid (ulcer of the genital region) and it enhances the transmission of HIV (which enhances Haemophilus ducreyi transmission in turn). This organism is an apparent extracellular pathogen that resists phagocytosis. Some of the virulence factors include an outer membrane serum resistance protein, as well as two toxins, cytolethal distending toxin (CDT) and hemolysin, both of which contribute to tissue destruction.