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Query: NC_011896:2775000:2788198 Mycobacterium leprae Br4923, complete genome

Start: 2788198, End: 2789208, Length: 1011

Host Lineage: Mycobacterium leprae; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain was isolated from a human skin biopsy in Brazil, and passaged in nude mice and armadillos. The bacterium is a close relative of M. tuberculosis. However, compared to the latter, the genome of M. leprae is smaller due to reductive genome evolution, with many important metabolic activities including siderophore production, part of the oxidative chain, most of the microaerophilic and anaerobic respiratory chains, and numerous catabolic systems and their regulatory circuits eliminated due to extensive recombination events between dispersed repetitive sequences. It is evident that this species has undergone massive genome reduction over time as a result of its parasitic nature, discarding more than half its genes and rendering it the most striking example of genome reduction in a microbial pathogen.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_002677:2775365:2788300278830027893101011Mycobacterium leprae TN, complete genomehypothetical protein0692
NC_015675:3046852:305214030521403052826687Mesorhizobium opportunistum WSM2075 chromosome, complete genomehypothetical protein4e-31135
NC_010939:1920781:193045219304521931081630Actinobacillus pleuropneumoniae serovar 7 str. AP76, completehypothetical protein1e-1894.4
NC_015510:834064:841639841639842226588Haliscomenobacter hydrossis DSM 1100 chromosome, complete genomehypothetical protein3e-0756.2
NC_008554:4088882:410762641076264108261636Syntrophobacter fumaroxidans MPOB, complete genomehypothetical protein5e-0652.4