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Query: NC_010723:298954:301323 Clostridium botulinum E3 str. Alaska E43, complete genome

Start: 301323, End: 301619, Length: 297

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was probably isolated from salmon eggs associated with a foodborne case of botulism in Alaska, however the exact details are not available. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009617:234782:237444237444237797354Clostridium beijerinckii NCIMB 8052 chromosome, complete genomeTrpR-like protein YerC/YecD2e-38157
NC_011898:1762000:176794517679451768253309Clostridium cellulolyticum H10, complete genomeTrpR like protein, YerC/YecD2e-28124
NC_009633:947695:969109969109969414306Alkaliphilus metalliredigens QYMF chromosome, complete genomeTrpR-like protein YerC/YecD6e-27119
NC_009253:2577316:258372625837262584052327Desulfotomaculum reducens MI-1 chromosome, complete genomeTrpR-like protein YerC/YecD4e-26116
NC_021171:358456:361333361333361647315Bacillus sp. 1NLA3E, complete genomehypothetical protein1e-25114
NC_006582:1138987:116560211656021165910309Bacillus clausii KSM-K16, complete genomehypothetical protein1e-24111
NC_014829:443500:464711464711465016306Bacillus cellulosilyticus DSM 2522 chromosome, complete genomeTrpR like protein, YerC/YecD2e-24111
NC_017347:2017097:203028020302802030582303Staphylococcus aureus subsp. aureus T0131 chromosome, completeTrpR-like protein YerC/YecD2e-21100
NC_016148:1105669:113156911315691131856288Thermovirga lienii DSM 17291 chromosome, complete genomeTrpR-like protein YerC/YecD2e-21100
NC_013522:991649:102108110210811021383303Thermanaerovibrio acidaminovorans DSM 6589, complete genomeTrpR like protein, YerC/YecD1e-2098.2
NC_010163:1361217:138363013836301383914285Acholeplasma laidlawii PG-8A chromosome, complete genomehypothetical protein4e-1889.7