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Query: NC_009699:2654672:2677509 Clostridium botulinum F str. Langeland chromosome, complete genome

Start: 2677509, End: 2678033, Length: 525

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum F strain Langeland was identified in 1958 from home-prepared liver paste involved in an outbreak of foodborne botulism on the island of Langeland, in Denmark. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_018664:1729794:173444117344411734908468Clostridium acidurici 9a chromosome, complete genomehypothetical protein2e-24112
NC_014964:1309845:132932113293211329785465Thermoanaerobacter brockii subsp. finnii Ako-1 chromosome, completehypothetical protein6e-21100
NC_015958:1422319:144113814411381441602465Thermoanaerobacter wiegelii Rt8.B1 chromosome, complete genomehypothetical protein6e-21100
NC_018515:3909646:390964639096463910200555Desulfosporosinus meridiei DSM 13257 chromosome, complete genomehypothetical protein2e-1684.7
NC_013385:90331:104545104545104991447Ammonifex degensii KC4, complete genomehypothetical protein8e-1683.2
NC_014960:1697818:170342717034271703888462Anaerolinea thermophila UNI-1, complete genomehypothetical protein2e-1479
NC_014831:1140356:114035611403561140955600Thermaerobacter marianensis DSM 12885 chromosome, complete genomehypothetical protein9e-1166.2
NC_011661:1143787:116194811619481162385438Dictyoglomus turgidum DSM 6724, complete genomevacuolar-type H+-ATPase subunit H2e-0858.9
NC_014248:943198:956713956713957258546Nostoc azollae 0708 chromosome, complete genomehypothetical protein9e-0753.1