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Query: NC_009495:280000:284038 Clostridium botulinum A str. ATCC 3502 chromosome, complete genome

Start: 284038, End: 284325, Length: 288

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a well-studied Hall strain that produces type A toxin. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010003:1577934:1583714158371415849551242Petrotoga mobilis SJ95, complete genomeputative transcriptional regulator, GntR family6e-1166.2
NC_015474:644552:6445526445526457781227Pyrococcus sp. NA2 chromosome, complete genomehypothetical protein8e-0958.9
NC_000868:196015:1960151960151972471233Pyrococcus abyssi GE5, complete genomeaminotransferase4e-0857
NC_000961:172610:1820001820001832861287Pyrococcus horikoshii OT3, complete genomehypothetical protein8e-0855.8
NC_016751:142237:1478811478811491281248Marinitoga piezophila KA3 chromosome, complete genometranscriptional regulator with HTH domain and aminotransferase domain2e-0754.3
NC_009615:1446132:1451260145126014524621203Parabacteroides distasonis ATCC 8503 chromosome, complete genomeaminotransferase4e-0753.5
NC_015954:463500:4753314753314765451215Halophilic archaeon DL31 chromosome, complete genomeputative GntR family transcriptional regulator5e-0753.1
NC_021184:504728:5106275106275121441518Desulfotomaculum gibsoniae DSM 7213, complete genometranscriptional regulator with HTH domain and aminotransferase domain2e-0651.2
NC_014623:3503218:3503218350321835044321215Stigmatella aurantiaca DW4/3-1 chromosome, complete genomeclass I and II family aminotransferase3e-0650.8
NC_010003:1724500:1726353172635317275341182Petrotoga mobilis SJ95, complete genomeputative transcriptional regulator, GntR family3e-0650.4
NC_013665:2132000:2136889213688921380971209Methanocella paludicola SANAE, complete genomeputative aminotransferase5e-0650.1
NC_021184:504728:5093825093825105751194Desulfotomaculum gibsoniae DSM 7213, complete genometranscriptional regulator with HTH domain and aminotransferase domain5e-0649.7
NC_013517:104480:1224811224811236711191Sebaldella termitidis ATCC 33386, complete genomeputative transcriptional regulator, GntR family5e-0649.7