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Query: NC_008261:2743942:2752571 Clostridium perfringens ATCC 13124, complete genome

Start: 2752571, End: 2752807, Length: 237

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: The species type strain, originally isolated from a human gas gangrene patient. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_006177:3457637:346149634614963461774279Symbiobacterium thermophilum IAM 14863, complete genomehypothetical protein1e-1685.1
NC_009922:315870:335404335404335691288Alkaliphilus oremlandii OhILAs, complete genomeprotein of unknown function DUF10218e-1579
NC_004193:35698:528885288853136249Oceanobacillus iheyensis HTE831, complete genomehypothetical protein4e-1476.6
NC_012034:2555447:255544725554472555719273Anaerocellum thermophilum DSM 6725, complete genomeprotein of unknown function DUF10214e-1270.1
NC_012121:139741:146679146679146942264Staphylococcus carnosus subsp. carnosus TM300, complete genomehypothetical protein6e-1269.3
NC_014624:551510:565607565607565876270Eubacterium limosum KIST612 chromosome, complete genomehypothetical protein8e-1165.9
NC_010376:606000:607808607808608047240Finegoldia magna ATCC 29328, complete genomehypothetical protein2e-1064.3
NC_015389:1610756:162817416281741628470297Coriobacterium glomerans PW2 chromosome, complete genomeprotein of unknown function DUF10212e-0858.2
NC_014363:1902868:192227319222731922572300Olsenella uli DSM 7084 chromosome, complete genomeprotein of unknown function DUF10215e-0856.6