Pre_GI: BLASTP Hits

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Query: NC_017297:2531750:2536503 Clostridium botulinum F str. 230613 chromosome, complete genome

Start: 2536503, End: 2536814, Length: 312

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_011830:1504497:152335915233591523718360Desulfitobacterium hafniense DCB-2, complete genomephage protein2e-24111
NC_007907:4500000:451721745172174517576360Desulfitobacterium hafniense Y51, complete genomehypothetical protein2e-24111
NC_018515:3411276:342634734263473426703357Desulfosporosinus meridiei DSM 13257 chromosome, complete genomehypothetical protein9e-24108
NC_020291:795500:852799852799853119321Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomephage protein1e-1994.7
NC_010723:915697:928522928522928851330Clostridium botulinum E3 str. Alaska E43, complete genomephage protein5e-1889.7
NC_013406:6052913:605437460543746054670297Paenibacillus sp. Y412MC10 chromosome, complete genomehypothetical protein5e-1373.2
NC_010001:3614314:362061436206143620937324Clostridium phytofermentans ISDg, complete genomehypothetical protein2e-0961.2
NC_015913:117966:148548148548148868321Candidatus Arthromitus sp. SFB-mouse-Japan, complete genomehypothetical protein2e-0961.2
NC_013315:1707293:171898417189841719244261Clostridium difficile CD196 chromosome, complete genomephage protein2e-0651.2