Pre_GI: BLASTP Hits

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Query: NC_009089:873295:886825 Clostridium difficile 630, complete genome

Start: 886825, End: 887769, Length: 945

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017179:805867:822427822427823371945Clostridium difficile BI1, complete genomeacetyl-CoA decarbonylase/synthase complex subunit delta0644
NC_013315:796313:812873812873813817945Clostridium difficile CD196 chromosome, complete genomeacetyl-CoA decarbonylase/synthase complex subunit delta0644
NC_013316:796895:810413810413811357945Clostridium difficile R20291, complete genomeputative carbon monoxide dehydrogenase/acetyl-CoA synthase complex, small subunit0644
NC_014614:1309203:132507513250751326019945Clostridium sticklandii, complete genomeCorrinoid/iron-sulfur protein; small subunit1e-124446
NC_014328:4073714:408220440822044083148945Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeCO dehydrogenase/acetyl-CoA synthase subunit delta3e-118424
NC_015519:586000:599427599427600365939Tepidanaerobacter sp. Re1 chromosome, complete genomeCO dehydrogenase/acetyl-CoA synthase subunit delta6e-106384
NC_015682:379373:3891763891763903841209Thermodesulfobacterium sp. OPB45 chromosome, complete genomeCO dehydrogenase/acetyl-CoA synthase subunit delta, TIM barrel6e-62238
NC_013849:627811:6394206394206407871368Ferroglobus placidus DSM 10642 chromosome, complete genomeCO dehydrogenase/acetyl-CoA synthase, delta subunit1e-43177
NC_015320:967701:9787619787619800291269Archaeoglobus veneficus SNP6 chromosome, complete genomeCO dehydrogenase/acetyl-CoA synthase subunit delta1e-43176
NC_005791:961500:9661969661969673501155Methanococcus maripaludis S2, complete genomeacetyl-CoA decarbonylase/synthase complex subunit delta2e-40166
NC_009634:349204:3572963572963584501155Methanococcus vannielii SB chromosome, complete genomeacetyl-CoA decarbonylase/synthase complex subunit delta1e-39164
NC_014002:1173561:1183759118375911850781320Methanohalophilus mahii DSM 5219 chromosome, complete genomeacetyl-CoA decarbonylase/synthase delta subunit3e-39162
NC_009975:1565865:1576931157693115780851155Methanococcus maripaludis C6, complete genomeCO dehydrogenase/acetyl-CoA synthase, delta subunit5e-39161
NC_018876:2760000:2767878276787827692091332Methanolobus psychrophilus R15 chromosome, complete genomeacetyl-CoA decarbonylase/synthase complex subunit delta1e-37157
NC_003552:1202909:1207517120751712088271311Methanosarcina acetivorans C2A, complete genomeacetyl-CoA decarbonylase/synthase complex subunit delta1e-37157
NC_003552:4714457:4747748474774847490581311Methanosarcina acetivorans C2A, complete genomeacetyl-CoA decarbonylase/synthase complex subunit delta1e-37157
NC_003901:2479613:2485385248538524866951311Methanosarcina mazei Go1, complete genomeacetyl-CoA decarbonylase/synthase complex subunit delta2e-35149
NC_003901:815389:8254618254618267711311Methanosarcina mazei Go1, complete genomeacetyl-CoA decarbonylase/synthase complex subunit delta2e-35149
NC_007355:499764:5217615217615230771317Methanosarcina barkeri str. fusaro chromosome 1, complete sequenceacetyl-CoA decarbonylase/synthase complex subunit delta2e-35149
NC_015574:2021300:2025646202564620268151170Methanobacterium sp. SWAN-1 chromosome, complete genomeacetyl-CoA decarbonylase/synthase complex subunit delta6e-34144
NC_009712:1185301:120783812078381208785948Candidatus Methanoregula boonei 6A8, complete genomeacetyl-CoA decarbonylase/synthase complex subunit delta2e-33143
NC_015216:434752:4472264472264483861161Methanobacterium sp. AL-21 chromosome, complete genomeCO dehydrogenase/acetyl-CoA synthase subunit delta3e-32139
NC_007355:499764:5203485203485217571410Methanosarcina barkeri str. fusaro chromosome 1, complete sequenceacetyl-CoA decarbonylase/synthase complex subunit gamma4e-0755.8
NC_003901:815389:8267758267758281871413Methanosarcina mazei Go1, complete genomeacetyl-CoA decarbonylase/synthase complex subunit gamma1e-0551.2