Query: NC_018750:3481476 Streptomyces venezuelae ATCC 10712, complete genome
Lineage: Streptomyces venezuelae; Streptomyces; Streptomycetaceae; Actinomycetales; Actinobacteria; Bacteria
General Information: Streptomyces venezuelae strain ATCC 10712, isolated from soil in Caracas, Venezuela in about 1948, grows in a diffuse and homogenous manner in a variety of liquid media, and in some sporulates to near completion. This organism produces a number of secondary metabolites which may be of industrial or pharmaceutical interest. Soil actinomycete.
Subject: NC_005956:1572500 Bartonella henselae str. Houston-1, complete genome
Lineage: Bartonella henselae; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria
General Information: Bartonella henselae str. Houston-1 (ATCC 49882) was isolated from human blood in Houston Texas. Causative agent of cat scratch fever. This group of alpha proteobacteria are unique among pathogens in that they cause angiogenic lesions. This organism was identified as the causative agent of cat scratch fever, a disease found commonly in children or in immunocompromised adults. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells.