Pre_GI Gene

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Host: NC_005956 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005956:1572500 Bartonella henselae str. Houston-1, complete genome

Host Lineage: Bartonella henselae; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: Bartonella henselae str. Houston-1 (ATCC 49882) was isolated from human blood in Houston Texas. Causative agent of cat scratch fever. This group of alpha proteobacteria are unique among pathogens in that they cause angiogenic lesions. This organism was identified as the causative agent of cat scratch fever, a disease found commonly in children or in immunocompromised adults. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
157276715738551089hypothetical proteinBLASTP
1578689157876577tRNA-MetQuickGO ontology
157887015789881195S ribosomal RNAQuickGO ontologyBLASTP
15790641581881281823S ribosomal RNAQuickGO ontologyBLASTP
1582282158235776tRNA-AlaQuickGO ontologyBLASTP
1582693158276977tRNA-IleQuickGO ontology
15831371584628149216S ribosomal RNAQuickGO ontologyBLASTP
15848301584997168hypothetical proteinBLASTP
158547715874832007hypothetical proteinBLASTP
158848115899381458hypothetical proteinBLASTP
15901311590685555RNA polymerase sigma-70 factorQuickGO ontologyBLASTP
15906931590896204hypothetical proteinBLASTP
15910631591860798two-component response regulatorQuickGO ontologyBLASTP
159188115928941014Sensory transduction histidine kinaseQuickGO ontologyBLASTP
15936421594025384hypothetical proteinBLASTP
15943781594827450hypothetical proteinBLASTP