Pre_GI: SWBIT SVG BLASTP

Query: NC_016788:655175 Corynebacterium diphtheriae HC04 chromosome, complete genome

Lineage: Corynebacterium diphtheriae; Corynebacterium; Corynebacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: They may be found as members of the normal microflora of humans, where these bacteria find a suitable niche in virtually every anatomic site. This organism is the best known and most widely studied species of the genus. It is the causal agent of the disease diphtheria, a deadly infectious disease spreading from person to person by respiratory droplets from the throat through coughing and sneezing. In the course of infection, the bacteria invade and colonize tissues of the upper respiratory tract, proliferate and produce exotoxin that inhibits protein synthesis and causes local lesions and systemic degenerative changes in the heart, muscles, peripheral nerves, liver and other vital organs.

Subject: NC_008542:2631138 Burkholderia cenocepacia HI2424 chromosome 1, complete sequence

Lineage: Burkholderia cenocepacia; Burkholderia; Burkholderiaceae; Burkholderiales; Proteobacteria; Bacteria

General Information: This organism (HI2424; BCC1) was isolated as part of a study to find this organism in natural environments. Samples taken from fields that were planted with onions in New York in 1999 and 2000 were examined and it was discovered that isolates were the same as ones that can infect CF patients. This species (genomovar III) is part of the Burkholderia cepacia complex, which consists of 9 closely related species, also known as genomovars. These organisms are commonly found in soil and all are opportunistic pathogens espcially in cystic fibrosis patients.