Query: NC_016751:1776669 Marinitoga piezophila KA3 chromosome, complete genome
Lineage: Marinitoga piezophila; Marinitoga; Thermotogaceae; Thermotogales; Thermotogae; Bacteria
General Information: Country: Pacific Ocean; Environment: Deep sea, Hydrothermal vent, Marine; Isolation: deep-sea hydrothermal vent chimney; Temp: Thermophile; Temp: 65C. Marinitoga piezophila was isolated from a deep-sea hydrothermal vent chimney at a depth of 2630 meters on the East-Pacific Rise. This organism grows best at a pressure of 40 MPa. This organism is a member of the Thermatogales and has the characteristic morphology of one or more cells contained in a sheath-like envelope which extends beyond the cell wall.
Subject: NC_009882:167350 Rickettsia rickettsii str. 'Sheila Smith', complete genome
Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria
General Information: This strain was isolated from from a patient with Rocky Mountain spotted fever. Causative agent for Rocky Mountain Spotted Fever. This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. Rickettsia rickettsii was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.