Pre_GI Gene

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Host: NC_009882 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009882:167350 Rickettsia rickettsii str. 'Sheila Smith', complete genome

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This strain was isolated from from a patient with Rocky Mountain spotted fever. Causative agent for Rocky Mountain Spotted Fever. This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. Rickettsia rickettsii was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
1673501688761527periplasmic serine proteaseQuickGO ontologyBLASTP
169030169773744hypothetical proteinBLASTP
169940170314375succinate dehydrogenase cytochrome b-556 subunitQuickGO ontologyBLASTP
17038017046990hypothetical proteinBLASTP
170459170836378succinate dehydrogenase hydrophobic membrane anchor proteinQuickGO ontologyBLASTP
1709701727601791succinate dehydrogenase flavoprotein subunitQuickGO ontologyBLASTP
172907173563657amino acid ABC transporter permease proteinQuickGO ontologyBLASTP
17372217411139030S ribosomal protein S12QuickGO ontologyBLASTP
17413817462048330S ribosomal protein S7QuickGO ontologyBLASTP
1746331767322100elongation factor GQuickGO ontologyBLASTP
17687617695176tRNA-TrpQuickGO ontology
177150177350201preprotein translocase subunit SecEQuickGO ontologyBLASTP
177366177944579transcription antitermination protein NusGQuickGO ontologyBLASTP
17821417865143850S ribosomal protein L11QuickGO ontologyBLASTP
17865717937672050S ribosomal protein L1QuickGO ontologyBLASTP
17948717999651050S ribosomal protein L10QuickGO ontologyBLASTP
18014018057143250S ribosomal protein L7L12QuickGO ontologyBLASTP
1815181856394122DNA-directed RNA polymerase subunit betaQuickGO ontologyBLASTP
1858971900154119DNA-directed RNA polymerase subunit betaQuickGO ontologyBLASTP