Query: NC_015731:1062824 Nitrosomonas sp. Is79A3 chromosome, complete genome Lineage: Nitrosomonas; Nitrosomonas; Nitrosomonadaceae; Nitrosomonadales; Proteobacteria; Bacteria General Information: Environment: Fresh water; Isolation: freshwater lake; Temp: Mesophile. Nitrosomonas sp. (strain Is79A3) is an aerobic, chemoautotrophic, Gram-negative bacterium isolated from freshwater lake. It oxidizes ammonia into nitrite. Nitrosomonas sp. are useful in treatment of industrial and sewage waste and in the process of bioremediation.
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General Information: Isolated from a patient in New York, USA, in 1995. This organism is a tick-borne (Ixodesspp.) obligate intracellular pathogen that infects humans and causes human granulocytic anaplasmosis as well as infecting several other types of animals. This organism produces a number of pathogenic factors that aid virulence. These include specific adhesins for neutrophils, virulence factors that inhibit both phagosome-lysozome fusion and production of reactive oxygen species that would normally kill the bacterium. The bacterium also inhibits programmed cell death of the neutrophil (apoptosis) and induces expression of interleukin-8, which causes neutrophil chemotaxis, thereby increasing the spread of the bacterium throughout the host organism.