Pre_GI: SWBIT SVG BLASTP

Query: NC_015275:3846260 Clostridium lentocellum DSM 5427 chromosome, complete genome

Lineage: Cellulosilyticum lentocellum; Cellulosilyticum; Lachnospiraceae; Clostridiales; Firmicutes; Bacteria

General Information: Isolation: River sediment with paper mill waste; Temp: Mesophile; Temp: 40C; Isolation:river sediment with paper mill waste; Country:United Kingdom: River Don, Scotland. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This is a cellulolytic bacterium isolated from river sediment containing paper-mill waste.

Subject: NC_010673:479552 Borrelia hermsii DAH, complete genome

Lineage: Borrelia hermsii; Borrelia; Spirochaetaceae; Spirochaetales; Spirochaetes; Bacteria

General Information: This strain was isolated from a case of relapsing fever in western Washington, USA. Borrelia hermsii is the causative agent of tick-borne relapsing fever in the western United States and Canada. Borrelia then multiplies rapidly, causing a generalized infection throughout the tick. While feeding, the tick passes the organism into a mammalian host through its infectious saliva. Relapsing fever is characterized by a period of chills, fever, headache, and malaise, an asymptomatic period, followed by another episode of symptoms. This cycle of relapsing is due to changes in the surface proteins of Borrelia, which allow it to avoid detection and removal by the host immune system. This antigenic variation is the result of homologous recombination of silent proteins into an expressed locus, causing partial or complete replacement of one serotype with another. These plasmids carry genes involved in antigenic variation and pathogenicity.