Query: NC_014909:219498 Candidatus Blochmannia vafer str. BVAF chromosome, complete genome
Lineage: Blochmannia vafer; Blochmannia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria
General Information: Candidatus Blochmannia is an obligate bacterial associate of Camponotus and related ant genera. Blochmannia vafer was isolated from Camponotus vafer workers and larvae collected from a single colony in the Coronado National Forest near Portal, Arizona, USA. Blochmannia is located within bacteriocytes, where the bacterial cells float freely in the host cytoplasm, and within oocytes of queens.
Subject: NC_008258:1934479 Shigella flexneri 5 str. 8401, complete genome
Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria
General Information: This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Shigella spp. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.