Pre_GI Gene

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Host: NC_008258 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008258:1934479 Shigella flexneri 5 str. 8401, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Shigella spp. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
19344791934850372putative tail attachment proteinQuickGO ontologyBLASTP
19348621935263402putative DNA-packaging proteinQuickGO ontologyBLASTP
193552719367231197ISSfl2 ORFQuickGO ontologyBLASTP
1937422193749675tRNA-GlyQuickGO ontology
1937500193757576tRNA-ThrQuickGO ontologyBLASTP
1937578193765477tRNA-ArgQuickGO ontologyBLASTP
1937656193773176tRNA-MetQuickGO ontologyBLASTP
19379081938492585putative Q antiterminator encoded by prophageQuickGO ontologyBLASTP
19385941938953360putative endonuclease encoded by cryptic prophageQuickGO ontologyBLASTP
19389531939141189putative bacteriophage proteinQuickGO ontologyBLASTP
19391571939459303IS600 ORF1QuickGO ontologyBLASTP
19396001940313714IS600 ORF2QuickGO ontologyBLASTP
19403541941046693IS629 ORF2QuickGO ontologyBLASTP
19410461941372327IS629 ORF1QuickGO ontologyBLASTP
19414241942197774hypothetical bacteriophage proteinQuickGO ontologyBLASTP
194229419439881695hypothetical proteinBLASTP
19451441945515372hypothetical proteinBLASTP
19473151947869555hypothetical proteinBLASTP
19502121951045834hypothetical proteinBLASTP
19511361951486351hypothetical proteinBLASTP
19515391951934396hypothetical proteinBLASTP
19519751952718744hypothetical proteinBLASTP
19527151953686972putative enzymeQuickGO ontologyBLASTP
19550581955423366IS2 ORF1QuickGO ontologyBLASTP
19554471956286840IS2 ORF2QuickGO ontologyBLASTP
195764119587411101putative cytochrome C-type proteinQuickGO ontologyBLASTP
19591291959875747copper homeostasis proteinQuickGO ontologyBLASTP
19598891960455567hypothetical proteinBLASTP
196067119624041734arginine tRNA synthetaseQuickGO ontologyBLASTP
19625811963069489hypothetical protein