Query: NC_013316:1 Clostridium difficile R20291, complete genome
Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria
General Information: Clostridium difficile R20291 was isolated in Stoke Mandeville Hospital, UK in 2006 and is closely related to the North American hypervirulent BI strains. Clostridium difficile, a Gram-positive, spore-forming anaerobic bacterium, is the leading cause of infectious diarrhea among patients in hospitals worldwide, causing C. difficile infection (CDI). An important nosocomial pathogen, it is frequently associated with antibiotic treatment and causes diseases ranging from antibiotic-associated diarrhea to life-threatening pseudomembraneous colitis.
Subject: NC_012917:569856 Pectobacterium carotovorum subsp. carotovorum PC1, complete genome
Lineage: Pectobacterium carotovorum; Pectobacterium; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria
General Information: Temp: Mesophile; Habitat: Host. Pectobacterium carotovorum causes soft-rot diseases of various plant hosts through degradation of the plant cell walls. Formerly Erwinia, these organisms are plant-specific pathogens that invade the vascular systems of plants. Pectobacterium colonize the intercellular spaces of plant cells and deliver potent effector molecules (Avr - avirulence) through a type III secretion system (Hrp - hypersensitive response and pathogenicity). Avr proteins control host-bacterium interactions, including host range. Expression of the plant cell-wall-degrading enzymes is controlled through a quorum-sensing mechanism that quantifies the number of Pectobacterium bacteria through measurement of the concentration of small molecules (acyl homoserine lactones) produced by Pectobacterium.