Query: NC_010804:996837 Burkholderia multivorans ATCC 17616 chromosome 1, complete
Lineage: Burkholderia multivorans; Burkholderia; Burkholderiaceae; Burkholderiales; Proteobacteria; Bacteria
General Information: Isolated from soil enriched with anthranilate at 41C, Berkeley, CA, USA. This species is associated with infections in cystic fibrosis patients. It is an important opportunistic pathogen, colonizing the lungs and associated with a decrease in long-term survival. This species is a member of the Burkholderia cepacia complex, although it does not appear to spread from patient to patient as do the other members of the group.
Subject: NC_006085:308567 Propionibacterium acnes KPA171202, complete genome
Lineage: Propionibacterium acnes; Propionibacterium; Propionibacteriaceae; Actinomycetales; Actinobacteria; Bacteria
General Information: Isolated from human skin. Acne causing bacterium. This bacterium is the most common gram-positive, non-spore forming, anaerobic rod encountered in clinical specimens. The causative agent of acne, it typically grows as an obligate anaerobe. Some strains are aerotolerant, but still show better growth as an anaerobe. It has the ability to produce propionic acid, as its name suggests. It also has the ability to produce catalase along with indole, nitrate, or both indole and nitrate. Propionibacterium resembles Corynebacterium in morphology and arrangement, but is non-toxigenic.It is a common resident of the pilosebaceous (hair follicle) glands of the human skin. The bacteria release lipases to digest a surplus of the skin oil, sebum, that has been produced. The combination of digestive products (fatty acids) and bacterial antigens stimulates an intense local inflammation that bursts the hair follicle. Since acne is caused in part from an infection, it can be suppressed with topical and oral antibiotics such as clindamycin, erythromycin, or tetracycline. Some other forms of therapy include chemicals that enhance skin removal or slow the production of sebum.