Pre_GI Gene

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Host: NC_006085 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_006085:308567 Propionibacterium acnes KPA171202, complete genome

Host Lineage: Propionibacterium acnes; Propionibacterium; Propionibacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Isolated from human skin. Acne causing bacterium. This bacterium is the most common gram-positive, non-spore forming, anaerobic rod encountered in clinical specimens. The causative agent of acne, it typically grows as an obligate anaerobe. Some strains are aerotolerant, but still show better growth as an anaerobe. It has the ability to produce propionic acid, as its name suggests. It also has the ability to produce catalase along with indole, nitrate, or both indole and nitrate. Propionibacterium resembles Corynebacterium in morphology and arrangement, but is non-toxigenic.It is a common resident of the pilosebaceous (hair follicle) glands of the human skin. The bacteria release lipases to digest a surplus of the skin oil, sebum, that has been produced. The combination of digestive products (fatty acids) and bacterial antigens stimulates an intense local inflammation that bursts the hair follicle. Since acne is caused in part from an infection, it can be suppressed with topical and oral antibiotics such as clindamycin, erythromycin, or tetracycline. Some other forms of therapy include chemicals that enhance skin removal or slow the production of sebum.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
3085673096131047hypothetical proteinBLASTP
309691310323633inorganic pyrophosphataseQuickGO ontologyBLASTP
3103153117451431putative carboxypeptidaseQuickGO ontologyBLASTP
311745312680936hypothetical proteinBLASTP
312708313262555putative hypoxanthine phosphoribosyltransferaseQuickGO ontologyBLASTP
3134043155572154putative cell division protein FtsHQuickGO ontologyBLASTP
315622316197576GTP cyclohydrolase IQuickGO ontologyBLASTP
316270316563294hypothetical proteinBLASTP
3168053179111107putative outer membrane protein AQuickGO ontologyBLASTP
317911318549639hypothetical proteinBLASTP
318444318707264hypothetical protein
318756319277522hypothetical proteinBLASTP
319307319759453hypothetical proteinBLASTP
319949320923975hypothetical proteinBLASTP
320859321536678hypothetical proteinBLASTP
321592322437846dihydropteroate synthaseQuickGO ontologyBLASTP
322498322860363dihydroneopterin aldolaseQuickGO ontologyBLASTP
322857323414558putative hydroxymethyldihydropteridine pyrophosphokinaseQuickGO ontologyBLASTP
323411323947537hypothetical proteinBLASTP
324030324707678hypothetical proteinBLASTP
3247843259741191putative NADH dehydrogenaseQuickGO ontologyBLASTP
326113326430318hypothetical proteinBLASTP
3266923292262535putative Clp-family ATP-binding proteaseQuickGO ontologyBLASTP