Pre_GI: SWBIT SVG BLASTP

Query: NC_010162:573709 Sorangium cellulosum 'So ce 56', complete genome

Lineage: Sorangium cellulosum; Sorangium; Polyangiaceae; Myxococcales; Proteobacteria; Bacteria

General Information: Sorangium cellulosum 'So ce 56' produces a large number of bioactive compounds, such as, the antifungal soraphen and the anticancer agent epothilone. This organism, like other myxobacteria, undergoes a complex development and differentiation pathway. When cell density increases, the organism switches to "social motility" where aggregates of cells can gather together into masses termed fruiting bodies that may consist of up to 100 000 cells. The motility system is not dependent on flagella like most bacteria, but instead relies on twitching pili: short extracellular appendages that may function analogously to oars in a rowboat. The myxobacteria have proved to be a rich source of novel natural products. Sorangium cellulosum produces a number of antibacterial, antifungal and cytotoxic substances which are being studies for therapeutic applications.

Subject: NC_008601:1658454 Francisella tularensis subsp. novicida U112, complete genome

Lineage: Francisella tularensis; Francisella; Francisellaceae; Thiotrichales; Proteobacteria; Bacteria

General Information: Avirulent species. Francisella novicida is closely related to Francisella tularensis, the causative agent for tularemia but is nonvirulent. This organism, however may cause disease in immunocompromised individuals. They do however cause a disease in mice that is very similar to tularemia. This strain was isolated from water in Utah, USA in 1950. Francisella tularensis is a non-motile, aerobic, rod-shaped Gram-negative bacterium and is the causative agent of tularemia.