Query: NC_009943:305854 Candidatus Desulfococcus oleovorans Hxd3, complete genome
Lineage: Desulfococcus oleovorans; Desulfococcus; Desulfobacteraceae; Desulfobacterales; Proteobacteria; Bacteria
General Information: An alkane-degrading sulfate-reducing Gram-negative bacterium isolated from the saline water phase of an oil-water separator from a northern German oil field. Desulfococcus oleovorans, originally designated Desulfobacterium oleovorans, was isolated using hexadecane as a carbon source and has been used to determine the mechanism of anaerobic hydrocarbon degradation.
Subject: NC_005956:1572500 Bartonella henselae str. Houston-1, complete genome
Lineage: Bartonella henselae; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria
General Information: Bartonella henselae str. Houston-1 (ATCC 49882) was isolated from human blood in Houston Texas. Causative agent of cat scratch fever. This group of alpha proteobacteria are unique among pathogens in that they cause angiogenic lesions. This organism was identified as the causative agent of cat scratch fever, a disease found commonly in children or in immunocompromised adults. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells.