Query: NC_009881:283500 Rickettsia akari str. Hartford, complete genome
Lineage: Rickettsia akari; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria
General Information: This strain was isolated from mites in Hartford. Causative agent of Rickettsialpox. Members of this genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens. In both groups, the bacteria are transmitted via an insect, usually a tick, to a host organism where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. Rickettsia akari causes a mild disease, Rickettsialpox, which is an acute fever-inducing illness transmitted by a hematophagous mite that infects the common house mouse and bites humans. Infection by this organism may be confused with anthrax due to the black eschar. This bacterium is a member of the spotted fever group of Rickettsiales and is endemic to New York, USA, but is also found in other cities in the USA, Russia, South Korea, and South Africa.
Subject: NC_006905:2805877 Salmonella enterica subsp. enterica serovar Choleraesuis str
Lineage: Salmonella enterica; Salmonella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria
General Information: This strain was isolated from a 58-year old man with sepsis and has been shown to be resistant to ciprofloxacin and ceftriaxone. This organism also causes severe disease (swine paratyphoid) in pigs. Causes enteric infections. This group of Enterobactericiae have pathogenic characteristics and are one of the most common causes of enteric infections (food poisoning) worldwide. They were named after the scientist Dr. Daniel Salmon who isolated the first organism, Salmonella choleraesuis, from the intestine of a pig. The presence of several pathogenicity islands (PAIs) that encode various virulence factors allows Salmonella spp. to colonize and infect host organisms. There are two important PAIs, Salmonella pathogenicity island 1 and 2 (SPI-1 and SPI-2) that encode two different type III secretion systems for the delivery of effector molecules into the host cell that result in internalization of the bacteria which then leads to systemic spread.