Query: NC_009655:195500 Actinobacillus succinogenes 130Z chromosome, complete genome
Lineage: Actinobacillus succinogenes; Actinobacillus; Pasteurellaceae; Pasteurellales; Proteobacteria; Bacteria
General Information: Succinate-producing bacterium. Originally isolated from bovine rumen, this species is one of the most promising succinate producers known. It can utilize a variety of sugars and produce a very high volume of succinate, which is used by the pharmaceutical industry. This organism has been improved over time by growth on fermentable carbon and sodium monofluoroacetate and selection of fluoroacetate-resistant mutants which have a higher succinate yield. The succinate yield has also been improved via a metabolic engineering approach, by cloning and overproducing the PEP-carboxykinase gene which catalyzes the addition of carbon dioxide to PEP to form oxalacetate and can work physiologically in both directions
Subject: NC_008767:1829500 Neisseria meningitidis FAM18, complete genome
Lineage: Neisseria meningitidis; Neisseria; Neisseriaceae; Neisseriales; Proteobacteria; Bacteria
General Information: Isolated from a patient with meningococcal septicemia. Causes septicemia and meningitis. The second of two pathogenic Neisseria, this organism causes septicemia and is the leading cause of life-threatening meningitis (inflammation of the meninges, the membrane surrounding the brain and spinal cord) in children. This organism typically residies in the nasopharynx cavity but can invade the respiratory epthelial barrier, cross into the bloodstream and the blood brain barrier, and cause inflammation of the meninges. Pathogenicity factors include the surface proteins (porins and opacity proteins), and the type IV pilus (which is also found in Neisseria gonorrhoeae). Pathogenicity factors include the surface proteins (porins and opacity proteins), and the type IV pilus (which is also found in Neisseria gonorrhoeae). This organism, like Neisseria gonorrhoeae, is naturally competent, and protein complexes at the cell surface recognize the uptake signal sequence in extracellular DNA, an 8mer that is found at high frequency in Neisseria chromosomal DNA.