Pre_GI: SWBIT SVG BLASTP

Query: NC_009648:4656187 Klebsiella pneumoniae subsp. pneumoniae MGH 78578, complete genome

Lineage: Klebsiella pneumoniae; Klebsiella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain was isolated from a patient in 1994. Opportunistic pathogen that causes multiple hospital-acquired infections. This organism is the most medically important organism within the genus Klebsiella. It is an environmental organism found in water, soil, and on the surface of plants. Several strains have been isolated from plant tissues and are nitrogen-fixing endophytes that may be a source of nitrogen for the plant. Other strains can become opportunistic pathogens which infect humans, and typically causes hospital-acquired infections in immunocompromised patients. Major sites of infection include the lungs, where it causes a type of pneumonia, and urinary tract infections. Klebsiella can also enter the bloodstream (bacterimia) and cause sepsis. The pathogen can also infect animals and cause inflammation of the uterus in horses as well as more generalized infections in other mammals. This organism expresses numerous pathogenicity factors, including multiple adhesins, capsular polysaccharide, siderophores, and lipopolysaccharide for the evasion of host defenses. The multiple antibiotic resistance genes carried on the chromosome inhibit efforts to clear the organism from infected patients via antibiotic use.

Subject: NC_013890:808791 Dehalococcoides sp. GT chromosome, complete genome

Lineage: Dehalococcoides mccartyi; Dehalococcoides; Dehalococcoidaceae; Dehalococcoidales; Chloroflexi; Bacteria

General Information: Temp: Mesophile; Habitat: Fresh water, Groundwater. Dehalococcoides sp. GT was isolated from an chloroethene-contaminated aquifer. This strain can dechlorinate trichloroethene and vinyl chloride. This organism was isolated from environments contaminated with organic chlorinated chemicals such as tetrachloroethene (PCE) and trichloroethane (TCE), common contaminants in the anaerobic subsurface. There are at least 15 organisms from different metabolic groups, halorespirators, acetogens, methanogens and facultative anaerobes, that are able to metabolize PCE. Some of these organisms couple dehalogenation to energy conservation and utilize PCE as the only source of energy while others dehalogenate tetrachloroethene fortuitously. This non-methanogenic, non-acetogenic culture is able to grow with hydrogen as the electron donor, indicating that hydrogen/PCE serves as an electron donor/acceptor for energy conservation and growth. This organism can only grow anaerobically in the presence of hydrogen as an electron donor and chlorinated compounds as electron acceptors. Dehalococcoides ethenogenes is typically found at sites contaminated with chlorinated solvents, and have been independently isolated in dozens of sites across the USA.