Query: NC_008618:1526392 Bifidobacterium adolescentis ATCC 15703, complete genome
Lineage: Bifidobacterium adolescentis; Bifidobacterium; Bifidobacteriaceae; Bifidobacteriales; Actinobacteria; Bacteria
General Information: Human gut bacterium. This species is a normal inhabitant of the healthy human gut. Newborns, especially those that are breast-fed, are colonized with Bifidobacteria within days after birth. This species was first isolated from the feces of a breast-fed infant. In one comprehensive 16S rDNA sequence-based enumeration of the colonic microbiota of three healthy adult humans it represents, on average, 0.008% of all 16S rDNA sequences and 4.302% of the sequences in its division (Eckburg et. They are saccharolytic organisms that produce acetic and lactic acids without generation of CO2, except during degradation of gluconate.
Subject: NC_005956:1402500 Bartonella henselae str. Houston-1, complete genome
Lineage: Bartonella henselae; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria
General Information: Bartonella henselae str. Houston-1 (ATCC 49882) was isolated from human blood in Houston Texas. Causative agent of cat scratch fever. This group of alpha proteobacteria are unique among pathogens in that they cause angiogenic lesions. This organism was identified as the causative agent of cat scratch fever, a disease found commonly in children or in immunocompromised adults. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells.