Pre_GI Gene

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Host: NC_005956 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005956:1402500 Bartonella henselae str. Houston-1, complete genome

Host Lineage: Bartonella henselae; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: Bartonella henselae str. Houston-1 (ATCC 49882) was isolated from human blood in Houston Texas. Causative agent of cat scratch fever. This group of alpha proteobacteria are unique among pathogens in that they cause angiogenic lesions. This organism was identified as the causative agent of cat scratch fever, a disease found commonly in children or in immunocompromised adults. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
140275814038461089hypothetical proteinBLASTP
1408680140875677tRNA-MetQuickGO ontology
140886114089791195S ribosomal RNAQuickGO ontologyBLASTP
14090551411872281823S ribosomal RNAQuickGO ontologyBLASTP
1412273141234876tRNA-AlaQuickGO ontologyBLASTP
1412684141276077tRNA-IleQuickGO ontology
14131281414619149216S ribosomal RNAQuickGO ontologyBLASTP
14148211414988168hypothetical proteinBLASTP
14153071415699393Transcriptional regulatorQuickGO ontologyBLASTP
141590514169661062Multidrug resistance protein vceAQuickGO ontologyBLASTP
141699014185611572Multidrug resistance protein vceBQuickGO ontologyBLASTP
14198191420397579AcetyltransferaseQuickGO ontologyBLASTP
142045714215901134Ornithine decarboxylaseQuickGO ontologyBLASTP
14216461421864219hypothetical proteinBLASTP
14234521424366915hypothetical proteinBLASTP
142447914251446662-keto-3-deoxy-6-phosphogluconate aldolaseQuickGO ontologyBLASTP