Query: NC_002689:78297 Thermoplasma volcanium GSS1, complete genome Lineage: Thermoplasma volcanium; Thermoplasma; Thermoplasmataceae; Thermoplasmatales; Euryarchaeota; Archaea General Information: This strain is the type strain for this species, and was isolated from a solfataric (volcanic area that gives off sulfuric gases) field. Thermophilic archaea. This organism is a thermophilic, acidophilic, archaea that was isolated from acidic hydrothermal vents on the shore of Aeolian Island of Vulcano, Italy. Growth of this facultative aerobe occurs at temperatures of 33-67°C with optimal at 60°C and pH of 1.0-4.0 (optimal 2.0).
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General Information: Bartonella henselae str. Houston-1 (ATCC 49882) was isolated from human blood in Houston Texas. Causative agent of cat scratch fever. This group of alpha proteobacteria are unique among pathogens in that they cause angiogenic lesions. This organism was identified as the causative agent of cat scratch fever, a disease found commonly in children or in immunocompromised adults. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells.