Query: NC_000868:196015 Pyrococcus abyssi GE5, complete genome
Lineage: Pyrococcus abyssi; Pyrococcus; Thermococcaceae; Thermococcales; Euryarchaeota; Archaea
General Information: This organism was isolated from an active chimney in the North Fiji Basin of the Pacific Ocean at a depth of 3500 meters. This organism is an obligate anaerobic, hyperthermophilic archaeon. Growth occurs at a temperature of 67-103 degrees C with optimal growth at 103 degrees C at 200 atmospheres of pressure. Increased hydrostatic pressure has been found to extend the upper growth temperature and stimulate growth.
Subject: NC_006142:243899 Rickettsia typhi str. Wilmington, complete genome
Lineage: Rickettsia typhi; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria
General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, is composed of obligate intracellular pathogens. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. Transovarial transmission (from mother to offspring) occurs in the invertebrate host. Rickettsia typhi causes murine typhus and is an obligate intracellular pathogen that infects both the flea vector and hosts such as human, rat, and mouse. In the flea vector, the bacterium penetrates the gut epithelial barrier and is found in the feces which become infective.