Pre_GI: SWBIT SVG BLASTN

Query: NC_017512:2087098 Neisseria meningitidis WUE 2594, complete genome

Lineage: Neisseria meningitidis; Neisseria; Neisseriaceae; Neisseriales; Proteobacteria; Bacteria

General Information: The second of two pathogenic Neisseria, this organism causes septicemia and is the leading cause of life-threatening meningitis (inflammation of the meninges, the membrane surrounding the brain and spinal cord) in children. This organism typically residies in the nasopharynx cavity but can invade the respiratory epthelial barrier, cross into the bloodstream and the blood brain barrier, and cause inflammation of the meninges. Pathogenicity factors include the surface proteins (porins and opacity proteins), and the type IV pilus (which is also found in Neisseria gonorrhoeae). This organism, like Neisseria gonorrhoeae, is naturally competent, and protein complexes at the cell surface recognize the uptake signal sequence in extracellular DNA, an 8mer that is found at high frequency in Neisseria chromosomal DNA.

Subject: NC_010407:316320 Clavibacter michiganensis subsp. sepedonicus chromosome, complete

Lineage: Clavibacter michiganensis; Clavibacter; Microbacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Causative agent of bacterial ring rot. Isolated from infected potato. This organism was first described and classified in 1914 as "Bacterium sepedonicus" and is considered a major plant pathogen. It is a phytopathogenic actinomycete that causes wilt and tuber rot in potato, which is a plant vascular disease with very high bacterial titers. Pathogenicity is believed to be associated with the presence of two plasmids, pCSL1 and pCSL2. This species is subdivided into five subspecies: michiganensis, sepedonicus, nebraskensis, tesselarius and insidiosus each of which infects specific hosts: tomato, potato, corn, wheat and alfalfa, respectively. Members of the Clavibacter genus are known to produce antimicrobial compounds.