Pre_GI: SWBIT SVG BLASTN

Query: NC_017512:2087098 Neisseria meningitidis WUE 2594, complete genome

Lineage: Neisseria meningitidis; Neisseria; Neisseriaceae; Neisseriales; Proteobacteria; Bacteria

General Information: The second of two pathogenic Neisseria, this organism causes septicemia and is the leading cause of life-threatening meningitis (inflammation of the meninges, the membrane surrounding the brain and spinal cord) in children. This organism typically residies in the nasopharynx cavity but can invade the respiratory epthelial barrier, cross into the bloodstream and the blood brain barrier, and cause inflammation of the meninges. Pathogenicity factors include the surface proteins (porins and opacity proteins), and the type IV pilus (which is also found in Neisseria gonorrhoeae). This organism, like Neisseria gonorrhoeae, is naturally competent, and protein complexes at the cell surface recognize the uptake signal sequence in extracellular DNA, an 8mer that is found at high frequency in Neisseria chromosomal DNA.

Subject: NC_008148:2156873 Rubrobacter xylanophilus DSM 9941, complete genome

Lineage: Rubrobacter xylanophilus; Rubrobacter; Rubrobacteraceae; Rubrobacterales; Actinobacteria; Bacteria

General Information: Cellulose-degrading bacterium. This genus contains two species: Rubrobacter radiotolerans and Rubrobacter xylanophilus. These two species represent the oldest lineage (deepest branch) of the Actinobacteria and are distantly related to Mycobacteria and Streptomycetes. Both species are thermophilic and exhibit high tolerance to radiation. Very little research has been done on these organisms and little is known other than their taxonomic characterization. Rubrobacter xylanophilus was isolated from a thermally polluted industrial runoff in the United Kingdom. Some strains of this species are capable of degrading hemicellulose and xylan (polymers of plant origin), and could play a significant role in the degradation of these compounds in the wood and paper industry as well as in the environment.